Measles immunity gaps among children and adolescents with HIV in Zambia despite high measles vaccination and antiretroviral therapy coverage.

ABSTRACT:

Objective

The study objective was to identify measles and rubella immunity gaps among people with HIV (PWH) in Zambia despite high measles vaccine coverage and widespread access to antiretroviral therapy.

Design

Nationally representative cross-sectional serosurvey using biorepository specimens.

Methods

Blood specimens collected in the Zambia Population HIV Impact Assessment survey (ZAMPHIA) of 2016 were tested for measles and rubella immunoglobulin G (IgG) antibodies by enzyme immunoassay. Hierarchical generalized additive models were fit to characterize age-specific measles and rubella seroprevalence profiles by HIV infection status. Log-binomial regression was performed to identify factors associated with seronegativity.

Results

Of the 25 383 specimens, a sub

SUBMITTER: Mutembo S 

PROVIDER: S-EPMC10664789 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature