The genetic basis of apparently idiopathic ventricular fibrillation: a retrospective overview.

ABSTRACT:

Aims

During the diagnostic work-up of patients with idiopathic ventricular fibrillation (VF), next-generation sequencing panels can be considered to identify genotypes associated with arrhythmias. However, consensus for gene panel testing is still lacking, and variants of uncertain significance (VUS) are often identified. The aim of this study was to evaluate genetic testing and its results in idiopathic VF patients.

Methods and results

We investigated 419 patients with available medical records from the Dutch Idiopathic VF Registry. Genetic testing was performed in 379 (91%) patients [median age at event 39 years (27-51), 60% male]. Single-gene testing was performed in 87 patients (23%) and was initiated more often in patients with idiopathic VF before 2010. Panel testing w

SUBMITTER: Verheul LM 

PROVIDER: S-EPMC10665040 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature