Ghrelin and glucagon-like peptide-1 according to body adiposity and glucose homeostasis.

ABSTRACT:

Objective

We investigated the biological behavior of ghrelin and glucagon-like peptide-1 (GLP-1) after a standard liquid meal according to body adiposity and glucose homeostasis.

Subjects and methods

This cross-sectional study included 41 individuals (92.7% women; aged 38.3 ± 7.8 years; BMI 32.2 ± 5.5 kg/m²) allocated into three groups according to body adiposity and glucose homeostasis, as follows: normoglycemic eutrophic controls (CON, n = 11), normoglycemic with obesity (NOB, n = 15), and dysglycemic with obesity (DOB, n = 15). They were tested at fasting and 30 and 60 min after the ingestion of a standard liquid meal in which we measured active ghrelin, active GLP-1, insulin, and plasma glucose levels.

Results

As expected, DOB exhibited th

SUBMITTER: Lopes KG 

PROVIDER: S-EPMC10665067 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature