Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.

ABSTRACT: A diverse set of biological processes have been implicated in the pathophysiology of Alzheimer's disease (AD) and related dementias. However, there is limited understanding of the peripheral biological mechanisms relevant in the earliest phases of the disease. Here, we used a large-scale proteomics platform to examine the association of 4877 plasma proteins with 25-year dementia risk in 10,981 middle-aged adults. We found 32 dementia-associated plasma proteins that were involved in proteostasis, immunity, synaptic function, and extracellular matrix organization. We then replicated the association between 15 of these proteins and clinically relevant neurocognitive outcomes in two independent cohorts. We demonstrated that 12 of these 32 dementia-associated proteins were associated with cereb

SUBMITTER: Walker KA 

PROVIDER: S-EPMC10665113 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature