Structure of the native myosin filament in the relaxed cardiac sarcomere.

ABSTRACT: The thick filament is a key component of sarcomeres, the basic units of striated muscle¹. Alterations in thick filament proteins are associated with familial hypertrophic cardiomyopathy and other heart and muscle diseases². Despite the central importance of the thick filament, its molecular organization remains unclear. Here we present the molecular architecture of native cardiac sarcomeres in the relaxed state, determined by cryo-electron tomography. Our reconstruction of the thick filament reveals the three-dimensional organization of myosin, titin and myosin-binding protein C (MyBP-C). The arrangement of myosin molecules is dependent on their position along the filament, suggesting specialized capacities in terms of strain susceptibility and force generation. Three

SUBMITTER: Tamborrini D 

PROVIDER: S-EPMC10665186 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature