CD201⁺ fascia progenitors choreograph injury repair.

ABSTRACT: Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation¹. Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin. Using skin injury models in mice, single-cell transcriptomics and genetic lineage tracing, ablation and gene deletion models, we demonstrate that CD201⁺ progenitors control the pace of wound healing by generating multiple specialized cell types, from proinflammatory fibroblasts to myofibroblasts, in a spatiotemporally tuned sequence. We identified retinoic acid and hypoxia signalling as the entry checkpoints into proinflammatory and myofibroblast states. Modulating CD201⁺ pro

SUBMITTER: Correa-Gallegos D 

PROVIDER: S-EPMC10665192 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature