Early-life stress perturbs the epigenetics of Cd36 concurrent with adult onset of NAFLD in mice.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the U.S. and worldwide. The roles of early postnatal life stress (EPLS) and the fatty acid translocase (CD36) on the pathogenesis of adult-onset NAFLD remain unknown. We hypothesized that EPLS, in the form of neonatal maternal separation (NMS), would predispose mice towards developing adult NAFLD, increase hepatic CD36 expression, and differentially methylate Cd36 promoter concurrently.

Methods

NMS was performed on mice from postnatal day 1 to 21 and a high-fat/high-sucrose (HFS) diet was started at 4 weeks of age to generate four experimental groups: Naive-control diet (CD), Naive-HFS, NMS-CD, and NMS-HFS.

Results

NMS alone caused NAFLD in adult male mice at 25 weeks of a

SUBMITTER: Fu Q 

PROVIDER: S-EPMC10665193 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature