Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.

ABSTRACT: Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)^1,2, conferring a predisposition to life-threatening COVID-19 pneumonia³. Here we report that patients with autosomal recessive NIK or RELB deficiency, or a specific type of autosomal-dominant NF-κB2 deficiency, also have neutralizing autoantibodies against type I IFNs and are at higher risk of getting life-threatening COVID-19 pneumonia. In patients with autosomal-dominant NF-κB2 deficiency, these autoantibodies are found only in individuals who are heterozygous for variants associated with both transcription (p52 activity) loss of function (LOF) due to impaired p100 processing to generate p5

SUBMITTER: Le Voyer T 

PROVIDER: S-EPMC10665196 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature