Posaconazole exposure in critically ill ICU patients: a need for action.

ABSTRACT:

Purpose

Posaconazole is an antifungal drug currently being used for prophylaxis and treatment of invasive fungal infections such as aspergillosis. To date, therapeutic drug monitoring (TDM) of posaconazole is recommended with the use of oral suspension, but the potential need of TDM with the use of IV formulations is rising. Therefore, we aimed to investigate the pharmacokinetics of IV posaconazole in critically ill patients.

Methods

In a prospective study, we analysed 168 consecutivelly collected posaconazole levels from 10 critically ill patients drawn during a 7 day curse. Posaconazole concentrations were measured using a chromatographic method. Demographic and laboratory data were collected, and the data was analysed using descriptive statistics.

Results

We includ

SUBMITTER: Konig C 

PROVIDER: S-EPMC10665255 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature