Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.

ABSTRACT: The pathology of depression is related to the imbalance of various neurotransmitters. The dorsal raphe nucleus (DRN), the main brain region producing 5-HT, is crucially involved in the pathophysiology of depression. It contains several neuron types, in which GABAergic neurons are activated by stimuli associated with negative experiences and 5-HT neurons are activated by reward signals. However, little is known about its underlying molecular mechanisms. Here, we found that p11, a multifunctional protein associated with depression, was down-regulated by chronic social defeat stress in 5-HT^DRN neurons. Knockdown of p11 in DRN induced depression-like behaviors, while its overexpression in 5-HT^DRN neurons alleviated depression-like behavior caused by chronic social defeat

SUBMITTER: Li W 

PROVIDER: S-EPMC10665321 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature