Monte Carlo based dosimetry of extraoral photobiomodulation for prevention of oral mucositis.

ABSTRACT: Photobiomodulation therapy (PBMT) is recommended for prevention and treatment of oral mucositis, a painful condition that occurs in cancer patients. Intraoral PBMT is limited to treating distal oral mucosa and oropharynx. Extraoral PBMT may provide a more efficient intervention. The goal of this study was to develop a clinically viable protocol for extraoral PBMT. Monte Carlo modeling was used to predict the distribution of 850 nm light for four treatment sites, using anatomical data obtained from MRI and optical properties from the literature. Simulated incident light power density was limited to 399 mW/cm² to ensure treatment safety and to prevent tissue temperature increase. The results reveal that total tissue thickness determines fluence rate at the oral mucosa, whereas the

SUBMITTER: Yaroslavsky AN 

PROVIDER: S-EPMC10665335 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature