Vulnerability and resilience to prenatal stress exposure: behavioral and molecular characterization in adolescent rats.

ABSTRACT: Exposure to stress can lead to long lasting behavioral and neurobiological consequences, which may enhance the susceptibility for the onset of mental disorders. However, there are significant individual differences in the outcome of stress exposure since only a percentage of exposed individuals may show pathological consequences, whereas others appear to be resilient. In this study, we aimed to characterize the effects of prenatal stress (PNS) exposure in rats at adolescence and to identify subgroup of animals with a differential response to the gestational manipulation. PNS adolescent offspring (regardless of sex) showed impaired emotionality in different pathological domains, such as anhedonia, anxiety, and sociability. However, using cluster analysis of the behavioral data we could iden

SUBMITTER: Creutzberg KC 

PROVIDER: S-EPMC10665384 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature