The effect of ginger extract on cisplatin-induced acute anorexia in rats.

ABSTRACT: Cisplatin is a platinum-based chemotherapeutic agent widely used to treat various cancers. However, several side effects have been reported in treated patients. Among these, acute anorexia is one of the most severe secondary effects. In this study, a single oral administration of 100 or 500 mg/kg ginger extract (GE) significantly alleviated the cisplatin-induced decrease in food intake in rats. However, these body weight and water intake decreases were reversed in the 100 mg/kg group rats. To elucidate the underlying mechanism of action, serotonin (5-HT) and 5-HT_2C, _3A, and ₄ receptors in the nodose ganglion of the vagus nerve were investigated. The results showed that cisplatin-induced increases in serotonin levels in both the blood and nodose ganglion tis

SUBMITTER: Kim H 

PROVIDER: S-EPMC10665510 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature