CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior.

ABSTRACT:

Introduction

The dopaminergic system plays a key role in the appropriate functioning of the central nervous system, where it is essential for emotional balance, arousal, reward, and motor control. The cell adhesion molecule close homolog of L1 (CHL1) contributes to dopaminergic system development, and CHL1 and the dopamine receptor D2 (D2R) are associated with mental disorders like schizophrenia, addiction, autism spectrum disorder and depression.

Methods

Here, we investigated how the interplay between CHL1 and D2R affects the behavior of young adult male and female wild-type (CHL+/+) and CHL1-deficient (CHL1-/-) mice, when D2R agonist quinpirole and antagonist sulpiride are applied.

Results

Low doses of quinpirole (0.02 mg/kg body weight) induced hypolocomotion of CH

SUBMITTER: Fernandes L 

PROVIDER: S-EPMC10665519 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature