Intraindividual phenotyping of depression in high-risk youth: An application of a multilevel hidden Markov model.

ABSTRACT:

Background

Traditionally, depression phenotypes have been defined based on interindividual differences that distinguish between subgroups of individuals expressing distinct depressive symptoms often from cross-sectional data. Alternatively, depression phenotypes can be defined based on intraindividual differences, differentiating between transitory states of distinct symptoms profiles that a person transitions into or out of over time. Such within-person phenotypic states are less examined, despite their potential significance for understanding and treating depression.

Methods

The current study used intensive longitudinal data of youths (N = 120) at risk for depression. Clinical interviews (at baseline, 4, 10, 16, and 22 months) yielded 90 weekly assessm

SUBMITTER: Liu Q 

PROVIDER: S-EPMC10665546 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature