COMT Val/Met, stressful life events and externalizing behaviors in youth: A longitudinal study from the ABCD sample.

ABSTRACT: Early adolescence is a crucial time for understanding and detecting the risk factors that may influence youth externalizing/disruptive behaviors and disorders. Previous literature reported evidence that risk factors for disruptive behaviors include catechol-O-methyltransferase (COMT) Val158Met (rs4680) polymorphism and environmental influences. An unanswered question is whether there is a change in these risk factors over stages of youth development. This longitudinal study examines the interaction effect of Val158Met and stressful life events (SLE) on youth externalizing behaviors from ages 9-11. Participants were 2363 children of European ancestry recruited as part of the Adolescent Brain Cognitive Development study. Repeated measures linear mixed models were used to examin

SUBMITTER: Kant T 

PROVIDER: S-EPMC10665666 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature