LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery.

ABSTRACT: Obesity is a major global public health issue involving dyslipidemia, oxidative stress, inflammation, and increased risk of CVD. Weight loss reduces this risk, but the biochemical underpinnings are unclear. We explored how obesity and weight loss after bariatric surgery influence LDL interactions that trigger proatherogenic versus antiatherogenic processes. LDL was isolated from plasma of six patients with severe obesity before (basal) and 6-12 months after bariatric surgery (basal BMI = 42.7 kg/m²; 6-months and 12-months postoperative BMI = 34.1 and 30 kg/m²). Control LDL were from six healthy subjects (BMI = 22.6 kg/m²). LDL binding was quantified by ELISA; LDL size and charge were assessed by chromatography; LDL biochemical composition was determined. Co

SUBMITTER: Jayaraman S 

PROVIDER: S-EPMC10665669 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature