Clinical characteristics of patients with KRAS mutation detected by liquid biopsy.

ABSTRACT:

Background

KRAS mutation positive lung cancer is known to be clinically characterized by older age, males, and smokers. It is reported to be more common in mucinous adenocarcinoma, but all reports are based on analysis of tissue samples. Recently, blood samples have become available for analysis, suggesting a low detection rate of circulating tumor DNA in histological types, especially mucinous adenocarcinoma. In this study, we investigated the clinical characteristics of KRAS mutation-positive cases in the analysis of blood specimens, as these remain unclear.

Methods

The clinical background of patients with KRAS mutation among those who underwent next-generation sequencing (NGS) analysis using blood samples was evaluated.

Results

NGS analysis was performed on 214 blo

SUBMITTER: Amino Y 

PROVIDER: S-EPMC10665783 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature