A data-driven computational model for obesity-driven diabetes onset and remission through weight loss.

ABSTRACT: Obesity is a major risk factor for the development of type 2 diabetes (T2D), where a sustained weight loss may result in T2D remission in individuals with obesity. To design effective and feasible intervention strategies to prevent or reverse T2D, it is imperative to study the progression of T2D and remission together. Unfortunately, this is not possible through experimental and observational studies. To address this issue, we introduce a data-driven computational model and use human data to investigate the progression of T2D with obesity and remission through weight loss on the same timeline. We identify thresholds for the emergence of T2D and necessary conditions for remission. We explain why remission is only possible within a window of opportunity and the way that window depends on the

SUBMITTER: Yildirim V 

PROVIDER: S-EPMC10665812 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature