MIRS: An AI scoring system for predicting the prognosis and therapy of breast cancer.

ABSTRACT: Tumor-infiltrating immune cells (TIICs) and metastasis are crucial characteristics for tumorigenesis. However, the potential role of their combination in breast cancer (BRCA) remains elusive. Herein, on the basis of quantifying TIICs and tumor metastasis together, we established a precise prognostic scoring system named metastatic and immunogenomic risk score (MIRS) using a neural network model. MIRS showed better performance when compared with other published signatures. MIRS stratifies patients into a high risk subtype (MIRS^high) and a low risk subtype (MIRS^low). The MIRS^high patients exhibit significantly lower survival rate compared with MIRS^low patients (P<0.0001), higher response to chemotherapy, but lower response to immunotherapy. Convers

SUBMITTER: Huang C 

PROVIDER: S-EPMC10665820 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature