The key role of depression and supramarginal gyrus in frailty: a cross-sectional study.

ABSTRACT:

Background

The age-related decrease in reserve and resistance to stressors is recognized as frailty, one of the most significant challenges identified in recent years. Despite a well-acknowledged association of frailty with cognitive impairment, depression, and gray matter morphology, no clear data are available regarding the nature of this relationship. This cross-sectional study aims to disentangle the role of the behavioral, neuropsychological, and neural components as predictors or moderators of frailty.

Methods

Ninety-six older adults (mean age = 75.49 ± 6.62) were consecutively enrolled and underwent a clinical and MRI (3 T) evaluation to assess frailty, physical activity, global cognitive level, depression, wellbeing, autonomy in daily living, cortical thickness, and

SUBMITTER: Isernia S 

PROVIDER: S-EPMC10665836 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature