Regional neuroinflammation induced by peripheral infection contributes to fatigue-like symptoms: a [¹⁸F]DPA-714 positron emission tomography study in rats.

ABSTRACT:

Introduction

A series of symptoms, including fever, widespread pain, fatigue, and even ageusia, have frequently been reported in the context of various infections, such as COVID-19. Although the pathogenic mechanisms underlying an infection causing fever and pain have been well established, the mechanisms of fatigue induced by infection in specific brain regions remain unclear.

Methods

To elucidate whether and how the peripheral infection cause fatigue via regional neuroinflammation, we performed a brain-wide investigation of neuroinflammation in a peripheral pseudoinfection rat model using [¹⁸F]DPA-714 positron emission tomography (PET) imaging analysis, in which the polyriboinosinic: polyribocytidylic acid (poly I:C) was intraperitoneally injected.

Results

SUBMITTER: Li D 

PROVIDER: S-EPMC10665845 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature