Use of Disease-Modifying Treatments in Patients With Sickle Cell Disease.

ABSTRACT:

Importance

Despite hydroxyurea being an established treatment for sickle cell disease (SCD), it remains underused. The recent approval of the disease-modifying treatments (DMTs) l-glutamine, crizanlizumab, and voxelotor underscores the need to understand the uptake of DMTs in the current treatment landscape.

Objective

To explore characteristics that may be associated with DMT use and to describe observed patterns of yearly DMT use from 2014 to 2021.

Design, setting, and participants

This cross-sectional study used administrative claims data from Optum's deidentified Clinformatics Data Mart Database from January 1, 2014, to September 30, 2021, to identify adults and children with SCD. Data were analyzed from August 1, 2022, to August 28, 2023.

Exposure

Use of DM

SUBMITTER: Newman TV 

PROVIDER: S-EPMC10665975 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature