Integrated genomic and functional analyses of human skin-associated <i>Staphylococcus</i> reveal extensive inter- and intra-species diversity.

ABSTRACT: Human skin is stably colonized by a distinct microbiota that functions together with epidermal cells to maintain a protective physical barrier. Staphylococcus, a prominent genus of the skin microbiota, participates in colonization resistance, tissue repair, and host immune regulation in strain-specific manners. To unlock the potential of engineering skin microbial communities, we aim to characterize the diversity of this genus within the context of the skin environment. We reanalyzed an extant 16S rRNA amplicon dataset obtained from distinct body sites of healthy volunteers, providing a detailed biogeographic depiction of staphylococcal species that colonize our skin. S. epidermidis, S. capitis, and S. hominis were the most abundant staphylococcal species presen

SUBMITTER: Joglekar P 

PROVIDER: S-EPMC10666031 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature