First-Line Osimertinib for Previously Untreated Patients With NSCLC and Uncommon EGFR Mutations: The UNICORN Phase 2 Nonrandomized Clinical Trial.

ABSTRACT:

Importance

Non-small cell lung cancer (NSCLC) with uncommon EGFR mutations is a rare subgroup, composing 14% of all EGFR mutations.

Objective

To determine the usefulness of osimertinib in previously untreated patients with metastatic NSCLC harboring uncommon EGFR mutations, excluding exon 20 insertion mutations.

Design, setting, and participants

This multicenter, open-label, single-group, phase 2 nonrandomized clinical trial enrolled patients from April 10, 2020, to May 31, 2022, with a follow-up of 6 months from the date the last patient was enrolled. The study enrolled 42 patients with uncommon EGFR mutations, of whom 40 were eligible.

Intervention

Osimertinib, 80 mg once daily, was administered orally to patients.

Main outcomes and measures

The primar

SUBMITTER: Okuma Y 

PROVIDER: S-EPMC10666043 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature