Ultra-Fast Ion Mobility Spectrometer for High-Throughput Chromatography.

ABSTRACT: Fast chromatography systems especially developed for high sample throughput applications require sensitive detectors with a high repetition rate. These high throughput techniques, including various chip-based microfluidic designs, often benefit from detectors providing subsequent separation in another dimension, such as mass spectrometry or ion mobility spectrometry (IMS), giving additional information about the analytes or monitoring reaction kinetics. However, subsequent separation is required at a high repetition rate. Here, we therefore present an ultra-fast drift tube IMS operating at ambient pressure. Short drift times while maintaining high resolving power are reached by several key instrumental design features: short length of the drift tube, resistor network of the drift tube, tri

SUBMITTER: Thoben C 

PROVIDER: S-EPMC10666085 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature