A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity.

ABSTRACT: In multiple sclerosis (MS), pathogenic T cell responses are known to be important drivers of autoimmune inflammation. However, increasing evidence suggests an additional role for B cells, which may contribute to pathogenesis via antigen presentation and production of proinflammatory cytokines. However, these B cell effector functions are not featured well in classical experimental autoimmune encephalomyelitis (EAE) mouse models. Here, we compared properties of myelin oligodendrocyte glycoprotein (MOG)-specific and polyclonal B cells and developed an adjuvant-free cotransfer EAE mouse model, where highly activated, MOG-specific induced germinal center B cells provide the critical stimulus for disease development. We could show that high levels of MOG-specific immunoglobulin G (IgGs) are not

SUBMITTER: Thomann AS 

PROVIDER: S-EPMC10666104 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature