Reevaluating progression and pathways following Mycobacterium tuberculosis infection within the spectrum of tuberculosis.

ABSTRACT: Traditional understanding of the risk of progression from Mycobacterium tuberculosis (Mtb) infection to tuberculosis (TB) overlooks diverse presentations across a spectrum of disease. We developed a deterministic model of Mtb infection and minimal (pathological damage but not infectious), subclinical (infectious but no reported symptoms), and clinical (infectious and symptomatic) TB, informed by a rigorous evaluation of data from a systematic review of TB natural history. Using a Bayesian approach, we calibrated the model to data from historical cohorts that followed tuberculin-negative individuals to tuberculin conversion and TB, as well as data from cohorts that followed progression and regression between disease states, disease state prevalence ratios, disease durat

SUBMITTER: Horton KC 

PROVIDER: S-EPMC10666121 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature