Prevailing Antagonistic Risks in Pleiotropic Associations with Alzheimer's Disease and Diabetes.

ABSTRACT:

Background

The lack of efficient preventive interventions against Alzheimer's disease (AD) calls for identifying efficient modifiable risk factors for AD. As diabetes shares many pathological processes with AD, including accumulation of amyloid plaques and neurofibrillary tangles, insulin resistance, and impaired glucose metabolism, diabetes is thought to be a potentially modifiable risk factor for AD. Mounting evidence suggests that links between AD and diabetes may be more complex than previously believed.

Objective

To examine the pleiotropic architecture of AD and diabetes mellitus (DM).

Methods

Univariate and pleiotropic analyses were performed following the discovery-replication strategy using individual-level data from 10 large-scale studies.

Results

We r

SUBMITTER: Kulminski AM 

PROVIDER: S-EPMC10666173 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature