Dataset Information

Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Postpartum depression (PPD) is a prevalent mental health condition affecting women globally within the first year following childbirth. Substance use during pregnancy has been associated with an increased risk of developing PPD, but the evidence remains inconclusive. This meta-analysis aims to comprehensively assess the effects of different substances on PPD risk, exploring potential modifiers and confounding factors.

Objectives

To examine the proportion of PPD among substance users during pregnancy, compared to non-users, and investigate the specific risk associated with different substances (tobacco, alcohol, and non-specified substance use/multiple substance use).

Methods

A systematic literature search was conducted from inception to November 2022 using the Web of Science database (Clarivate Analytics), incorporating Web of Science Core Collection, the BIOSIS Citation Index, the KCI-Korean Journal Database, MEDLINE^®, the Russian Science Citation Index, the SciELO Citation Index, and the Cochrane Central Register of Reviews, and Ovid/PsycINFO databases. Inclusion criteria comprised original studies with pregnant women, using validated depression scales and substance use reporting.

Results

Among the 26 included studies, encompassing 514,441 women, the pooled prevalence of PPD among substance users during pregnancy was 29% (95% CI 25-33). Meta-analyzes revealed an overall odds ratio (OR) of 3.67 (95% CI 2.31-5.85, p < 0.01) indicating a significantly higher risk of PPD among substance users compared to non-users. Subgroup analyzes demonstrated a higher risk for women with non-specified or multiple substance use (OR 4.67, 95% CI 2.59-8.41; p < 0.01) and tobacco use (OR 4.01, 95% CI 2.23-7.20; p < 0.01). Alcohol use showed a trend toward higher risk that did not reach statistical significance (OR 1.88, 95% CI 1.00-3.55; p = 0.051).

Conclusion

This meta-analysis provides evidence of an increased risk of PPD among pregnant substance users, particularly those using multiple substances or tobacco. However, caution is needed in interpreting the association with alcohol use due to its non-significant result.

Systematic review registration

This study protocol was registered at PROSPERO (registration number: CCRD42022375500).

SUBMITTER: Pacho M

PROVIDER: S-EPMC10666188 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis.

Pacho Malein M Aymerich Claudia C Pedruzo Borja B Salazar de Pablo Gonzalo G Sesma Eva E Bordenave Marta M Dieguez Rodrigo R Lopez-Zorroza Itziar I Herrero Jon J Laborda Maria M Fernandez-Rivas Aranzazu A Garcia-Rizo Clemente C Gonzalez-Torres Miguel Angel MA Catalan Ana A

Frontiers in psychiatry 20231109

<h4>Introduction</h4>Postpartum depression (PPD) is a prevalent mental health condition affecting women globally within the first year following childbirth. Substance use during pregnancy has been associated with an increased risk of developing PPD, but the evidence remains inconclusive. This meta-analysis aims to comprehensively assess the effects of different substances on PPD risk, exploring potential modifiers and confounding factors.<h4>Objectives</h4>To examine the proportion of PPD among ...[more]

PMID: 38025481

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Dataset Information

Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis.

Introduction

Objectives

Methods

Results

Conclusion

Systematic review registration

Publications

Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis.

Similar Datasets

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