Clinical and molecular characteristics of methicillin-resistant Staphylococcus aureus in bone and joint infection among children.

ABSTRACT:

Objective

To investigate the characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) in bone and joint infection (BJI) among children.

Methods

A total of 338 patients diagnosed with BJI from 2013 to 2022 in Children's Hospital of Fudan University were enrolled. Demographic information, microbiology culture results and laboratory findings, including white blood counts (WBC), C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), and erythrocyte sedimentation rate (ESR) were collected and analyzed. MRSA was confirmed by antimicrobial susceptibility testing. Other MRSA-caused infections were randomly selected for comparison. Twenty-three virulence and antimicrobial resistance (AMR) genes were screened for MRSA strains. Multilocus sequence typing (MLS

SUBMITTER: Fu P 

PROVIDER: S-EPMC10666310 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature