Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case-control study.

ABSTRACT:

Background

Regulatory T cells (Tregs) are involved in the systemic immune response after ischemic stroke. However, their role remains unclear, and the effect appears to be both neuroprotective and detrimental. Treg suppressor function may result in immunodepression and promote stroke-associated infection (SAI). Thus we assume that the bidirectional effects of Tregs may be in part attributed to the intracellular transcription factor Helios. Tregs with Helios expression (H+ Tregs) constitute 70-90% of all Treg cells and more frequently than Helios-negative Tregs (H- Tregs) express molecules recognized as markers of Tregs with suppressor abilities.

Methods and results

We prospectively assessed the circulating Treg population with flow cytometry in 52 subjects on days 1, 3, 10 a

SUBMITTER: Lukasik M 

PROVIDER: S-EPMC10666369 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature