Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories.

ABSTRACT:

Background

Cognitive complaints are often regarded as an early sign of Alzheimer's disease (AD) but may also occur in several other conditions and contexts. This study examines the correlates of cognitive complaint trajectories over a 5-year period in individuals who shared similar objective cognitive trajectories.

Methods

We analyzed a subsample (n = 1748) of the MEMENTO cohort, consisting of individuals with subjective cognitive decline or mild cognitive impairment at baseline. Participants were stratified based on their latent MMSE trajectory over a 5-year period: "high and increasing," "subtle decline," and "steep decline." Within each of the three strata, we used a latent-class longitudinal approach to identify distinct trajectories of cognitive complaints. We then used

SUBMITTER: Cacciamani F 

PROVIDER: S-EPMC10666380 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature