Targeting oncogenic TERT promoter variants by allele-specific epigenome editing.

ABSTRACT:

Background

Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. Silencing of such dominantly activated oncogenic alleles, thus, is a promising strategy to treat cancer. Recently, allele-specific epigenome editing (ASEE) has been described as a means to reduce transcription of genes in an allele-specific manner. In cancer, specificity to an oncogenic allele can be reached by either targeting directly a pathogenic single-nucleotide variant or a polymorphic single-nucleotide variant linked to the oncogenic allele. To investigate the potential of ASEE in cancer, we here explored this approach by targeting variants at the TERT promoter region. The TERT promoter region has been described as one of the most frequently mu

SUBMITTER: Kouroukli AG 

PROVIDER: S-EPMC10666398 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature