Identifying the driver miRNAs with somatic copy number alterations driving dysregulated ceRNA networks in cancers.

ABSTRACT:

Background

MicroRNAs (miRNAs) play critical roles in cancer initiation and progression, which were critical components to maintain the dynamic balance of competing endogenous RNA (ceRNA) networks. Somatic copy number alterations (SCNAs) in the cancer genome could disturb the transcriptome level of miRNA to deregulate this balance. However, the driving effects of SCNAs of miRNAs were insufficiently understood.

Methods

In this study, we proposed a method to dissect the functional roles of miRNAs under different copy number states and identify driver miRNAs by integrating miRNA SCNAs profile, miRNA-target relationships and expression profiles of miRNA, mRNA and lncRNA.

Results

Applying our method to 813 TCGA breast cancer (BRCA) samples, we identified 29 driver miRNAs wh

SUBMITTER: Dou R 

PROVIDER: S-EPMC10666415 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature