Risk assessment of aflatoxin B₁ in herbal medicines and plant food supplements marketed in Malaysia using margin of exposure and RISK21 approaches.

ABSTRACT: Aflatoxin B₁ (AFB₁) is a mycotoxin produced by several species of Aspergillus fungi which can cause liver cancer in animals and humans. This study aims to perform the risk assessment of AFB₁ in herbal medicines and plant food supplements (PFS) in Malaysian market. A total of 31 herbal medicines and PFS were purchased through online platforms and over the counter using a targeted sampling strategy. Of 31 samples analysed using the ELISA method, 25 (80.6%) were contaminated with AFB₁ at levels ranged from 0.275 to 13.941 μg/kg. The Benchmark Dose Lower Confidence level of 10 (BMDL₁₀) of 63.46 ng/kg bw/day and the estimated dietary intake of the adult population ranged from 0.006 to 10.456 ng/kg bw/day were used to calculate the Margin of

SUBMITTER: Ab Dullah SS 

PROVIDER: S-EPMC10666461 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature