Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration.

ABSTRACT: The causes of nigrostriatal cell death in idiopathic Parkinson's disease are unknown, but exposure to toxic chemicals may play some role. We followed up here on suggestions that bacterial secondary metabolites might be selectively cytotoxic to dopaminergic neurons. Extracts from Streptomyces venezuelae were found to kill human dopaminergic neurons (LUHMES cells). Utilizing this model system as a bioassay, we identified a bacterial metabolite known as aerugine (C₁₀H₁₁NO₂S; 2-[4-(hydroxymethyl)-4,5-dihydro-1,3-thiazol-2-yl]phenol) and confirmed this finding by chemical re-synthesis. This 2-hydroxyphenyl-thiazoline compound was previously shown to be a product of a wide-spread biosynthetic cluster also found in the human microbiome and in several pathogens. Ae

SUBMITTER: Uckert AK 

PROVIDER: S-EPMC10666548 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature