Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [¹⁸F]FPEB and PET Study in Male and Female Rats.

ABSTRACT:

Background

Females are twice as likely to experience post-traumatic stress disorder (PTSD) than males, yet specific factors contributing to this greater risk are not fully understood. Our clinical and recent preclinical findings suggest a role for the metabotropic glutamate receptor 5 (mGlu5) in PTSD and differential involvement between males and females.

Methods

Here, we further investigate whether mGlu5 receptor availability may contribute to individual and sex differences in PTSD susceptibility by quantifying receptor availability using the mGlu5 receptor-specific radiotracer, [¹⁸F]FPEB, and positron emission tomography in male (n = 16) and female (n = 16) rats before and after traumatic footshock exposure (FE) and assessment of stress-enhanced fear learning (S

SUBMITTER: Asch RH 

PROVIDER: S-EPMC10666551 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature