High blood pressure mediated the effect of fasting insulin level on nonalcoholic fatty liver disease risk: A Mendelian randomization study.

ABSTRACT:

Objective

The interactions between fasting insulin levels, high blood pressure and nonalcoholic fatty liver disease (NAFLD) are still unclear. We examined the causal mechanisms between these three cardiometabolic traits using Mendelian randomization (MR) approach by utilizing genetic instruments.

Methods

Three different genome-wide association studies resources of European ancestry were utilized for the present study. Two-sample MRs were used to assess causal effects between fasting insulin levels, high blood pressure and NAFLD. Multivariate MR was used to calculate the mediating effect. The inverse variance-weighted method was used as the main analysis method.

Results

Our study confirmed a causal effect of fasting insulin levels (IVW-OR = 9.54, P = 0.001) and

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10666686 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature