Plasma SARS-CoV-2 RNA elimination and RAGE kinetics distinguish COVID-19 severity.

ABSTRACT:

Objectives

Identifying biomarkers causing differential SARS-CoV-2 infection kinetics associated with severe COVID-19 is fundamental for effective diagnostics and therapeutic planning.

Methods

In this work, we applied mathematical modelling to investigate the relationships between patient characteristics, plasma SARS-CoV-2 RNA dynamics and COVID-19 severity. Using a straightforward mathematical model of within-host viral kinetics, we estimated key model parameters from serial plasma viral RNA (vRNA) samples from 256 hospitalised COVID-19⁺ patients.

Results

Our model predicted that clearance rates distinguish key differences in plasma vRNA kinetics and severe COVID-19. Moreover, our analyses revealed a strong correlation between plasma vRNA kinetics and plasm

SUBMITTER: Deng X 

PROVIDER: S-EPMC10666810 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature