Adolescent Growth Spurt and Type 2 Diabetes Risk in Southwestern American Indians.

ABSTRACT: Early puberty onset is associated with higher risk of diabetes, but most studies have not accounted for childhood factors that may confound the association. Using data from a study conducted in an Indigenous community in Arizona (1965-2007), we examined associations of timing and velocity of the adolescent growth spurt with type 2 diabetes, and whether these associations are mediated by childhood body mass index and insulinemia. Adolescent growth parameters were derived from the Preece-Baines growth model, a parametric growth curve fitted to longitudinal height data, for 861 participants with height measurements spanning the whole period of growth. In males, older age at take-off, age at peak velocity, and age at maturation were associated with decreased prevalence of diabetes (odds ratio

SUBMITTER: Ramirez-Luzuriaga MJ 

PROVIDER: S-EPMC10666964 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature