Dynamics and durability of HIV-1 neutralization are determined by viral replication.

ABSTRACT: Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet available, only data from HIV-1 neutralizers-persons with HIV-1 who naturally develop broad and potent nAbs-can inform about the dynamics and durability of nAb responses in humans, knowledge which is crucial for the design of future HIV-1 vaccine regimens. To address this, we assessed HIV-1-neutralizing immunoglobulin G (IgG) from 2,354 persons with HIV-1 on or off antiretroviral therapy (ART). Infection with non-clade B viruses, CD4⁺ T cell counts <200 µl^-1, being off ART and a longer time off ART were independent predictors of a more potent and broad neutralization. In longitudinal anal

SUBMITTER: Schommers P 

PROVIDER: S-EPMC10667105 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature