Modular access to alkylgermanes via reductive germylative alkylation of activated olefins under nickel catalysis.

ABSTRACT: Carbon-introducing difunctionalization of C-C double bonds enabled by transition-metal catalysis is one of most straightforward and efficient strategies to construct C-C and C-X bonds concurrently from readily available feedstocks towards structurally diverse molecules in one step; however, analogous difunctionalization for introducing germanium group and other functionalities remains elusive. Herein, we describe a nickel-catalyzed germylative alkylation of activated olefins with easily accessible primary, secondary and tertiary alkyl bromides and chlorogermanes as the electrophiles to form C-Ge and C-C_alkyl bonds simultaneously. This method provides a modular and facile approach for the synthesis of a broad range of alkylgermanes with good functional group compatibility, and ca

SUBMITTER: Gu R 

PROVIDER: S-EPMC10667229 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature