Moracin E and M isolated from Morus alba Linne induced the skeletal muscle cell proliferation via PI3K-Akt-mTOR signaling pathway.

ABSTRACT: Twigs of Morus alba have been used in traditional medicine to treat muscle-related symptoms such as aches, numbness, and stiffness. Despite its clinical use in traditional medicine, its active compounds and mode of action have not yet been investigated. Therefore, we aimed to isolate the compounds from the twigs of M. alba and deduce active compounds, key gene targets, and mechanism of action against sarcopenia using network pharmacology analysis. Using various isolation techniques and spectroscopic methods, 43 phytochemicals, including 3 new flavonoids, were isolated and performed network pharmacology analysis. According to the computational-assistant analysis, 28 compounds, 9 genes, and the PI3K-Akt-mTOR signaling pathway were deduced as expected active compounds (EAC), key targets, and

SUBMITTER: Kwak HJ 

PROVIDER: S-EPMC10667267 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature