A three-dimensional model with two-body interactions for endothelial cells in angiogenesis.

ABSTRACT: We introduce a three-dimensional mathematical model for the dynamics of vascular endothelial cells during sprouting angiogenesis. Angiogenesis is the biological process by which new blood vessels form from existing ones. It has been the subject of numerous theoretical models. These models have successfully replicated various aspects of angiogenesis. Recent studies using particle-based models have highlighted the significant influence of cell shape on network formation, with elongated cells contributing to the formation of branching structures. While most mathematical models are two-dimensional, we aim to investigate whether ellipsoids also form branch-like structures and how their shape affects the pattern. In our model, the shape of a vascular endothelial cell is represented as a spheroid

SUBMITTER: Sakai K 

PROVIDER: S-EPMC10667370 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature