Axitinib targets cardiac fibrosis in pressure overload-induced heart failure through VEGFA-KDR pathway.

ABSTRACT:

Background

There are no specific clinical medications that target cardiac fibrosis in heart failure (HF). Recent studies have shown that tyrosine kinase inhibitors (TKIs) may benefit fibrosis in various organs. However, there is limited research on their application in cardiac fibrosis. Axitinib, an FDA-approved tyrosine kinase inhibitor, was used to evaluate its effects on cardiac fibrosis and function in pressure overload-induced heart failure.

Methods

To build a pharmacological network, the pharmacological targets of axitinib were first retrieved from databases and coupled with key heart failure gene molecules for analysis and prediction. To validate the results outlined above, 8-week-old male C57BL/6 J mice were orally administrated of axitinib (30 mg/kg) daily for 8 wee

SUBMITTER: Jiao T 

PROVIDER: S-EPMC10667428 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature