Biomechanical and tissue reaction: the effects of varying sutures size on canine abdominal wall stitching.

ABSTRACT:

Objective

Larger diameter sutures can provide sufficient tensile strength to surgical incisions but may exacerbate the inflammatory response caused by the amount of implanted foreign material. This experiment aims to investigate the differences in biomechanical stability and tissue reactivity after suturing canine midline abdominal incisions with different suture sizes.

Method

Assessing the biomechanical differences between USP 2-0, 3-0, and 4-0 PGA sutures using uniaxial tensile testing on ex vivo canine midline skin and fascial muscle tissues using either a simple continuous or simple interrupted technique. mRNA and protein expression levels of inflammatory factors were measured through RT-PCR and ELISA. Tissue reactivity was evaluated using a semi-quantitative scor

SUBMITTER: Li S 

PROVIDER: S-EPMC10667435 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature