PTPRC functions as a prognosis biomarker in the tumor microenvironment of cutaneous melanoma.

ABSTRACT: Cutaneous melanoma is one of the most malignant types of skin cancer, with an extremely poor prognosis. Immune cells infiltrated in the tumor microenvironment (TME) affects melanoma initiation, progression, prognosis and immunotherapy strategies in melanoma. The potential utility of TME-related genes as a prognostic model for melanoma and as a predictor of immunotherapeutic response merits further exploration. In this study, we determined that an immune-related gene, protein tyrosine phosphatase receptor type C (PTPRC), was positively correlated with the positive prognosis of melanoma patients. Integration of this gene with TNM classification created a predictive model that showed better performance in determining overall survival than others. PTPRC expression was positively correlated wit

SUBMITTER: Li X 

PROVIDER: S-EPMC10667527 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature