Biochemical transformations of inorganic nanomedicines in buffers, cell cultures and organisms.

ABSTRACT: The field of nanomedicine is rapidly evolving, with new materials and formulations being reported almost daily. In this respect, inorganic and inorganic-organic composite nanomaterials have gained significant attention. However, the use of new materials in clinical trials and their final approval as drugs has been hampered by several challenges, one of which is the complex and difficult to control nanomaterial chemistry that takes place within the body. Several reviews have summarized investigations on inorganic nanomaterial stability in model body fluids, cell cultures, and organisms, focusing on their degradation as well as the influence of corona formation. However, in addition to these aspects, various chemical reactions of nanomaterials, including phase transformation and/or the forma

SUBMITTER: Neuer AL 

PROVIDER: S-EPMC10667590 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature