Heterogeneity of colon and rectum cancer incidence across 612 SEER counties, 2000-2014.

ABSTRACT: Recent analyses have suggested decreases over time in colorectal cancer incidence at older ages (≥55 years) but increases at younger ages (20-54 years). Understanding the geographic heterogeneity of incidence facilitates resource allocation for potential interventions and advances our knowledge of differential etiologies for these cancers. We performed age-period-cohort analysis using 2000-2014 county-level incidence from the Surveillance, Epidemiology, and End Results (SEER) database, estimating relative risk (RR) and age-adjusted annual percent change (Net Drifts) simultaneously for 612 counties via a hierarchical model, separately for colon and rectum cancer, stratified by age group (20-54 vs. 55-84). We also studied correlates of RR and Net Drift with various county-level characteristi

SUBMITTER: Chernyavskiy P 

PROVIDER: S-EPMC10667616 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature